It is important to note that there is currently no clinical research on the use of Amanita Muscaria for depression or its potential as a substitute for microdosing antidepressants.
However, there are indications that an imbalance in GABA and glutamate levels could be associated with this widespread condition. It is known, though, that antidepressants such as ketamine and benzodiazepines have shown promise in the treatment of depression, targeting specific neural pathways.
Some experts speculate that an imbalance between inhibitory and excitatory neurons plays a crucial role in the development of depression. Ketamine, an antagonist of glutamate receptors, has been proven to increase glutamate levels in the brain, leading to a rapid improvement in depressive symptoms.
On the other hand, benzodiazepines primarily act on GABA-A receptors to alleviate anxiety symptoms. However, due to their addictive nature and potential side effects, they are not suitable for long-term use as antidepressants.
Given that the active compounds in the fly agaric, Ibotenic acid, and Muscimol, interact with the glutamate-and GABA-systems, it can be assumed that Amanita Muscaria may also influence depression.
According to informal reports, notable benefits of Amanita Muscaria include the reduction of anxiety and an increase in energy. However, further research is essential to confirm its effectiveness in treating depression and ensure its long-term safety when used.
Conclusion:
The practice of microdosing AM is becoming increasingly popular, which means that it is of great importance to understand the potential effects. There is no question that this is safer than taking high doses of this potent mushroom, but little is known about the long-term health consequences.
Anyone considering taking Amanita muscaria should thoroughly research the subject and carefully weigh up the pros and cons. Furthermore, it is important to approach the dosage carefully, as this is extremely individual and the active ingredient strength of each mushroom can vary greatly.